Post Doctoral Fellow

Hello humankindness Located conveniently in the heart of Phoenix, Arizona,St. Joseph's Hospital and Medical Center is a 571-bed, not-for-profit hospital that provides a wide range of health, social and support services. Founded in 1895 by the Sisters of Mercy, St. Joseph's was the first hospital in the Phoenix area. More than 125 years later, St. Joseph's remains dedicated to its mission of caring for the poor and underserved. We are extremely proud to be a nationally recognized center for quality quaternary care, medical education and research. St. Joseph's includes the internationally renowned Barrow Neurological Institute, Norton Thoracic Institute, Cancer Center at St. Joseph's, Ivy Brain Tumor Center, and St. Joseph's Level I Trauma Center (which is verified by the American College of Surgeons). The hospital is also a respected center for high-risk obstetrics, neuro-rehabilitation, orthopedics, and other medical services. St. Joseph’s is considered a sought-after destination hospital for treating the most complex cases from throughout the world. Every day, approximately 20 percent of the hospital’s patients have traveled from outside of Arizona and the United States to seek treatment at St. Joseph’s. U.S News & World Report routinely ranks St. Joseph's among the top hospitals in the United States for neurology and neurosurgery. In addition, St. Joseph's boasts the Creighton University School of Medicine at St. Joseph's, and a strategic alliance with Phoenix Children's Hospital. St. Joseph's is consistently named an outstanding place to work and one of Arizona's healthiest employers. Come grow your career with one of Arizona's Most Admired Companies.

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Postdoctoral Position in slice electrophysiology and calcium imaging.

This postdoctoral fellow position will coordinate several projects aimed at studying neurophysiology in neurodegenerative disease both in the enteric nervous system and in brain slices. This includes studies evaluating enteric neuron function the role of alpha-synuclein in symptomology and the evaluation of lead candidates on synaptic function. The fellow will participate in the day-to-day operations of the research lab; duties will include collaborative experimental design conducting experimental laboratory work analyzing and writing up results for publication in peer-reviewed journals. In addition opportunities to learn about current laboratory operations including pre-clinical model techniques post-mortem analyses of tissue sample preparation; tissue sectioning immunohistochemistry etc.

Required Education/Experience/Skills:

Doctoral degree in natural sciences and at least four years of experience working in a basic science laboratory.

Skills required include a strong working knowledge of electrophysiology (patch-clamping) calcium imaging and associated techniques.

Experience with pre-clinical models primary neuronal cell culture immunohistochemistry neurophysiology and microscopy are highly desired.

Position requires software usage for data generation and handling data interpretation writing up laboratory procedures and results. Good command of written and spoken English is required.

Desired Education/Experience/Skills:

Advanced molecular biology techniques such as cloning recombinant protein production and protein analysis.

AAV production brain anatomy enteric nervous system function tissue sectioning immunohistochemistry and microscopy specifically in fluorescence immunolabeling; pre-clinical model techniques behavioral testing- working knowledge of levodopa-induced dyskinesia is a plus.

Research leading to Doctoral degree.  PhD or MD required.

Ability to conceive new/innovative ideas or solutions with good logic and problem solving skills; ability to communicate, write, advise and counsel on extremely complex and technical matters.